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All Journal Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Hemera Zoa Jurnal Ilmu Komputer dan Informasi Jurnal Veteriner Majalah Kedokteran Bandung Jurnal Ilmu Ternak dan Veteriner INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Medik Veteriner Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Farmamedika (Pharmamedica Journal) Jurnal Dunia Gizi Jurnal Kedokteran Hewan
Ekowati Handharyani
Department Of Clinic, Reproduction And Pathology, Faculty Of Veterinary Medicine, IPB University, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Gizi dan Pangan

 1 
IDENTIFIKASI KOMPONEN KIMIA DAN AKTIVITAS ANTIOKSIDAN DALAM TANAMAN TORBANGUN (Coleus amboinicus Lour) Trini Suryowati; Rimbawan Rimbawan; Rizal M Damanik; Maria Bintang; Ekowati Handharyani
Jurnal Gizi dan Pangan Vol. 10 No. 3 (2015)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.092 KB) | DOI: 10.25182/jgp.2015.10.3.%p

Abstract

ABSTRACTThe objective of this study was to determine the chemical compound in leaves, stem, and root by GC-MS technique and antioxidant activity of torbangun leaves (Coleus amboinicus Lour). The torbangun leaves ethanol extract were tested to antioxidant activity assay using DPPH, and á-glucosidase inhibitory effects was measured with a spectrophotometric method. The analysis of leaves revealed the presence of Carbamic acid, monoammonium salt (CAS) Ammonium carbamate (11.73%), Hexadecanoic acid (CAS) Palmitic acid (8.35%), I-Limonene (5.92%), Heptadecene-(8)- carbonic acid-(1) (4.76%), Oxacycloheptadec-8-en-2-one (CAS) Ambrettolide (4.70%). The analysis of stem revealed the presence of Formamide (CAS) Methanamide (22.48%), 12,13- Dimethyl-2,7- dioxa 5,10 diazatricyclo [4.4.4.0(1,6)] trans -tetradecan-12 (13.22%), Hexadecanoic acid (CAS) Palmitic acid (11.51%), 2-Propanone, 1-hydroxy- (CAS) Acetol (10.14%), 9-Octadecen-1-ol, (Z)- (CAS) cis-9-Octadecen-1-ol (7.09%). The analysis of roots revealed the presence of Methanamine, N-methyl- (CAS) Dimethylamine (28.45%), Acetic acid (CAS) Ethylic acid (9.78%), 3.2-Propanone, 1-hydroxy- (CAS) Acetol (6.41%), 1-Propen-2-ol, acetate (CAS) Isopropenyl acetate (5.16%), 4.73 Phenol, 2-methoxy- (CAS) Guaiacol(4.73%). The DPPH result of torbangun leaves ethanol extract obtained by IC50 247,942 ppm and ascorbic acid standard was 1 ppm. IC50 values inhibition of á-glucosidase extract was >100 ppm and glucobay standard was 0.264 ppm. This research provided a chemical compound and the torbangun leaves ethanol extract capable of acting as antioxidant based on IC50 values.Keywords: antioxidant activity, chemical compound, Coleus amboinicus LourABSTRAKPenelitian ini bertujuan untuk mengetahui komponen senyawa kimia dalam daun, dahan, dan akar menggunakan analisis Kromatografi Gas-Spektrometri Massa (GC-MS) serta aktivitas antioksidan daun torbangun (Coleus amboinicus Lour). Daun torbangun yang diekstrak etanol dianalisis aktivitas antioksidan menggunakan test DPPH, dan daya hambat enzim á-glukosidase diukur dengan metode spektrofotometer. Hasil analisis dalam daun menunjukkan komponen kimia Carbamic acid, monoammonium salt (CAS) Ammonium carbamate (11,73%), Hexadecanoic acid (CAS) Palmitic acid (8,35%), I-Limonene (5,92%), Heptadecene-(8)-carbonic acid-(1) (4,76%), Oxacycloheptadec-8-en-2-one (CAS) Ambrettolide (4,70%). Hasil analisis dalam dahan menunjukkan komponen kimia Formamide (CAS) Methanamide (22,8%), 12,13-Dimethyl-2,7-dioxa5,10diaza tricyclo [4.4.4.0(1,6)] trans-tetradecan-12 (13,22%), Hexadecanoic acid (CAS) Palmitic acid (11,51%), 2-Propanone,1-hydroxy-(CAS) Acetol (10,14%), 9-Octadecen-1-ol, (Z)- (CAS) cis-9-Octadecen-1-ol (7,09%). Hasil analisis dalam akar menunjukkan komponen kimia Methanamine, N-methyl-(CAS) Dimethylamine (28,45%), Acetic acid (CAS) Ethylic acid (9,78%), 3.2-Propanone, 1- hydroxy- (CAS) Acetol (6,41%), 1-Propen-2-ol, acetate (CAS) Isopropenyl acetate (5,16%), 4.73 Phenol, 2-methoxy- (CAS) Guaiacol (4,73%). Hasil uji antioksidan terhadap daun torbangun dengan metode DPPH didapatkan IC50 247,942 ppm dibandingkan standar vitamin C 1 ppm. Nilai IC50 dari penghambatan enzim á-glukosidase dalam ekstrak daun torbangun >100 ppm dibandingkan dengan standar glukobay 0,264 ppm. Hasil penelitian ini menunjukkan bahwa daun torbangun yang diekstrak dengan etanol mampu berperan sebagai antioksidan berdasarkan nilai IC50.Kata kunci: aktivitas antioksidan, Coleus amboinicus Lour, komponen kimia
Pemberian minyak ikan lele (Clarias gariepinus) terhadap bobot badan dan perubahan histopatologi hati, ginjal, dan otak tikus galur Sprague dawley yang diberi pakan hiperkolesterolemia Hardi Firmansyah; Katrin Roosita; Clara Meliyanti Kusharto; Ekowati Handharyani
Jurnal Gizi dan Pangan Vol. 12 No. 2 (2017)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (799.823 KB) | DOI: 10.25182/jgp.2017.12.2.85-92

Abstract

The objective of this study was to analyze changes in body weight and cell morphology in liver, kidney and brain tissue of Sprague dawley rats administered  hypercholesterolemia diets for four weeks. Four diet treatments were applied in this study: control, catfish oil, catfish oil with the addition of omega 3 and catfish oil with the addition of omega 3 and vitamin E. Four weeks after the intervention, the rats were sacrificed and the internal organs (liver, brain, and kidney) were taken for histological preparations by hematoxylin-eosin (HE) and immunohistochemistry test. The study showed that the catfish oil intervention tend to reduced weight gain of rats fed hypercholesterolemia diets. More lipid accumulation in liver of the control group was found than the intervention groups. However, there was no difference in the histopathology of the kidney and brain tissues between the control group and intervention groups. It is concluded that catfish oil study provides a positive effect in rat liver tissue, but no difference exists between the brain and kidney tissue. There is no defect found at hippocampus of rats by formed of amyloid plague.
Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats Putri Puncak Anjani; Evy Damayanthi; Rimbawan Rimbawan; Ekowati Handharyani
Jurnal Gizi dan Pangan Vol. 13 No. 1 (2018)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.349 KB) | DOI: 10.25182/jgp.2018.13.1.47-54

Abstract

The study aimed to analyze the potential of okra to reduction blood glucose and MDA liver in streptozotocin (STZ)-induced diabetic rats. Design experiment used in this study was pre and post test controlled group design. The first step of this study was analyzed bioactive compound of okra extract. The next step was administired orally of okra extract to control and diabetic rats induced by streptozotocin 50 mg/kgBW for 14 days. Sprague dawley rats were divided into six groups: normal control (N), diabetic control (DM), diabetic treated with green okra extract (GOE) with the dosage of 5 mg/kgBW quercetin and 10 mg/kgBW quercetin, diabetes treated with purple okra extract (POE) with the dosage of 5 mg/kgBW quercetin and 10 mg/kgBW quercetin. Blood glucose were measured each five days and malondialdehyde (MDA) liver in rats were measured in the end of intervention. The following results show that phenolic and quercetin of purple okra extract were higher (3.60%; 0.45 mg/g) than green okra extract (3.58%; 0.27 mg/g). Administration of GOE I, GOE II, POE I and POE II in diabetic rats showed significant (P<0.05) reduction in blood glucose level (115.25 mg/dl; 86 mg/dl; 180.75 mg/dl; 91 mg/dl) and improve level of MDA. These results suggest that intervention of okra extract based on quercetin compound show an antihyperglicemic potential and improve MDA level.
Co-Authors ., Chairul A Winarto Adi Winanto Adi Winarto Agus Buono Agus Setiyono Akhmad Endang Zainal Hasan Aziz Kustiyo Bambang Kiranadi Bambang Sumiarto Bambang Widyo Prastowo BIBIANA W LAY Chairul - Chairul Chairul Clara Meliyanti Kusharto Clara Meliyanti Kusharto DENI NOVIANA DEWI APRI ASTUTI Dewi Ratih Agungpriyono Dhany Nugraha Ramdhany Dondin Sajuthi Eflisa Endah Putri Elly Munadziroh Erni Sulistiawati Erwin Erwin Etriwati E Evy Damayanthi Geneva Ariesta Gunanti . Handayu Untari Hapsari Mahatmi Hardi Firmansyah Hernomoadi . Hernomoadi Hernomoadi Irma Herawati Suparto K Ochiai Katrin Roosita Kiranadi Bambang Komariah Komariah Komariah Lili Andriani M.B. Malole . Maria Bintang Masdiana C. Padaga Masriani . Ni Luh Putu Ika Mayasari Novera Nirmalasanti Octarina Octarina Okti Nadia Poetri Putri Puncak Anjani R. Susanti Retno Damajanti Soejoedono Retno Damayanti Soejoedono Rimbawan , Risti Rosmiati Rizal M Damanik Ruqiah Ganda Putri Panjaitan safrina dyah hardiningtyas Sangko Sayuti Nasution Sophia Setyawati sri murtini . Sri Purwaningsih Sri Rahmatul Laila Sri Wahyuni Surachmi Setiyaningsih Tanjung Penataseputro Trini Suryowati Wasmen Manalu Wiwin Winarsih Yuli Purwandari Kristiangingrum Yuni Andriani Yusuf Ridwan Zulfa Zakiah